EPIT

Epithalon

A synthetic tetrapeptide, Ala-Glu-Asp-Gly. No receptor target for it has been established in the published literature, and the sequence is short enough that it is not obviously derived from any human protein. The blank is the finding, not an omission.

No registered human study names Epithalon as an intervention. ClinicalTrials.gov holds no trial of it, so there is no trial evidence to read — a fact about the public record rather than proof the compound does nothing. No FDA-approved product contains Epithalon. 3 papers naming it were published in the last ten years.

Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Counts include only trials whose registered intervention names Epithalon; the registry search is fuzzy, so every match is re-checked. None of this says whether Epithalon works or is safe.

FDA status

Research only

Human studies

0

Furthest phase

Papers, 10 yr

3

Readership

5,080

monthly average, Feb–Jul 2026

Tracking since 2026-07-29 · About this data

What has actually been tested in humans

X

No registered human study

0

Registered human studies

None

No FDA-approved product contains it

No study of Epithalon in humans is registered on ClinicalTrials.gov. That is a fact about the public record, not a statement that the compound does nothing — but it does mean there is no trial evidence to read, and anyone telling you otherwise should be asked for the registration number. The grade is mechanical: it is computed from the registry and the FDA record alone, and it grades how much is known, never whether a compound is good or safe. Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Check the query.

What Epithalon is, and what it has been studied for

Epithalon is tracked here.

No registered trial names Epithalon as an intervention, so there is no condition it has been formally studied in. It does have a literature: 3 indexed papers name it in the last ten years. That work is laboratory and animal research, and a paper is not a trial.

Is anyone studying Epithalon?

Papers published each year that name Epithalon in the title or abstract, with the clinical trials that started in the same year marked beneath. Ten calendar years.

0123417181920212223242526
Vertical axis: papers published that year. Bar for 2026 is hatched because that year is still running.
Publications and trials naming Epithalon, by year
YearPublicationsTrials startedComplete year
201700Yes
201800Yes
201900Yes
202000Yes
202100Yes
202200Yes
202300Yes
202410Yes
202510Yes
202610No

3 papers between 2017 and 2026. A paper counts when “Epithalon” appears in its title or abstract — phrase-matched, so a paper mentioning the words separately is not counted. The total is a single query over the whole window, which is why it does not equal the bars added together: PubMed files a paper under both its electronic and its print publication date, so one paper can appear in two years. Publication volume measures scientific attention, not whether a compound works: a well-studied compound can be well-studied and ineffective. Sources: PubMed and ClinicalTrials.gov · collected 2026-08-02.

Published research on Epithalon

3 indexed papers name Epithalon in their title or abstract. These are the 8 PubMed ranks most relevant. Listing a paper is not a judgement about it, and none of these is summarised here — follow the link and read what it says.

  1. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

    Rahman OF, Lee SJ, Seeds WAJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2026

    PMID 4149020010.5435/JAAOSGlobal-D-25-00236

  2. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties

    Araj SK, Brzezik J, Mądra-Gackowska K, et al.International journal of molecular sciences2025

    PMID 4014133310.3390/ijms26062691

  3. Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice

    Anisimov VN, Khavinson VKh, Alimova IN, et al.Bulletin of experimental biology and medicine2002

    PMID 1245984810.1023/a:1021104819170

  4. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology

    Anisimov SV, Bokheler KR, Khavinson VKh, et al.Bulletin of experimental biology and medicine2002

    PMID 1236035610.1023/a:1015859322630

  5. Aging of the pineal gland

    Khavinson VKh, Golubev AGAdvances in gerontology = Uspekhi gerontologii2002

    PMID 12096440

  6. Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice

    Rosenfeld SV, Togo EF, Mikheev VS, et al.Bulletin of experimental biology and medicine2002

    PMID 1236035110.1023/a:1015899003974

  7. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

    Khavinson VKh, Bondarev IE, Butyugov AABulletin of experimental biology and medicine2003

    PMID 1293768210.1023/a:1025493705728

  8. Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats

    Khavinson VKh, Egorova VV, Timofeeva NM, et al.Bulletin of experimental biology and medicine2002

    PMID 1242007110.1023/a:1019878224754

Collected 2026-08-02from PubMed, phrase-matched on “Epithalon” in title and abstract. Run the same search.

About Epithalon

A synthetic tetrapeptide, Ala-Glu-Asp-Gly. No receptor target for it has been established in the published literature, and the sequence is short enough that it is not obviously derived from any human protein. The blank is the finding, not an omission.

Also known as
Epitalon · Epithalone · AEDG peptide

Structure and mechanism only. Nothing above describes what this compound is for, and no dose appears anywhere on this page.

Reading on this compound

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