AOD

AOD-9604

A synthetic peptide corresponding to residues 176 to 191 of human growth hormone, with a tyrosine added at the N-terminus. It is a fragment, not the hormone: it lacks the regions of growth hormone that bind the growth hormone receptor. No receptor target for the fragment itself has been established in the published literature, so none is stated here.

No registered human study names AOD-9604 as an intervention. ClinicalTrials.gov holds no trial of it, so there is no trial evidence to read — a fact about the public record rather than proof the compound does nothing. No FDA-approved product contains AOD-9604. 4 papers naming it were published in the last ten years.

Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Counts include only trials whose registered intervention names AOD-9604; the registry search is fuzzy, so every match is re-checked. None of this says whether AOD-9604 works or is safe.

FDA status

Research only

Human studies

0

Furthest phase

Papers, 10 yr

4

Readership

26

monthly average, Apr–Jul 2026

Tracking since 2026-07-29 · About this data

What has actually been tested in humans

X

No registered human study

0

Registered human studies

None

No FDA-approved product contains it

No study of AOD-9604 in humans is registered on ClinicalTrials.gov. That is a fact about the public record, not a statement that the compound does nothing — but it does mean there is no trial evidence to read, and anyone telling you otherwise should be asked for the registration number. The grade is mechanical: it is computed from the registry and the FDA record alone, and it grades how much is known, never whether a compound is good or safe. Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Check the query.

What AOD-9604 is, and what it has been studied for

AOD-9604 is classified by ChEMBL as a protein, and appears in trial registrations under LAT-8881 and LAT8881.

No registered trial names AOD-9604 as an intervention, so there is no condition it has been formally studied in. It does have a literature: 4 indexed papers name it in the last ten years. That work is laboratory and animal research, and a paper is not a trial.

Is anyone studying AOD-9604?

Papers published each year that name AOD-9604 in the title or abstract, with the clinical trials that started in the same year marked beneath. Ten calendar years.

0123417181920212223242526
Vertical axis: papers published that year. Bar for 2026 is hatched because that year is still running.
Publications and trials naming AOD-9604, by year
YearPublicationsTrials startedComplete year
201700Yes
201800Yes
201900Yes
202000Yes
202100Yes
202200Yes
202300Yes
202400Yes
202500Yes
202640No

4 papers between 2017 and 2026. A paper counts when “AOD9604” appears in its title or abstract — phrase-matched, so a paper mentioning the words separately is not counted. The total is a single query over the whole window, which is why it does not equal the bars added together: PubMed files a paper under both its electronic and its print publication date, so one paper can appear in two years. Publication volume measures scientific attention, not whether a compound works: a well-studied compound can be well-studied and ineffective. Sources: PubMed and ClinicalTrials.gov · collected 2026-08-02.

Published research on AOD-9604

4 indexed papers name AOD-9604 in their title or abstract. These are the 8 PubMed ranks most relevant. Listing a paper is not a judgement about it, and none of these is summarised here — follow the link and read what it says.

  1. Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions

    Rahman OF, Lee SJ, Seeds WAJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2026

    PMID 4149020010.5435/JAAOSGlobal-D-25-00236

  2. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance

    Mendias CL, Awan TMSports medicine (Auckland, N.Z.)2026

    PMID 4196663910.1007/s40279-026-02437-0

  3. AOD-9604 Metabolic

    Wilding JCurrent opinion in investigational drugs (London, England : 2000)2004

    PMID 15134286

  4. Detection and in vitro metabolism of AOD9604

    Cox HD, Smeal SJ, Hughes CM, et al.Drug testing and analysis2015

    PMID 2520851110.1002/dta.1715

  5. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model

    Kwon DR, Park GYAnnals of clinical and laboratory science2015

    PMID 26275694

  6. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice

    Heffernan M, Summers RJ, Thorburn A, et al.Endocrinology2001

    PMID 1171321310.1210/endo.142.12.8522

  7. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone

    Ng FM, Sun J, Sharma L, et al.Hormone research2000

    PMID 1114636710.1159/000053183

  8. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

    Heffernan MA, Thorburn AW, Fam B, et al.International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity2001

    PMID 1167376310.1038/sj.ijo.0801740

Collected 2026-08-02from PubMed, phrase-matched on “AOD9604” in title and abstract. Run the same search.

About AOD-9604

A synthetic peptide corresponding to residues 176 to 191 of human growth hormone, with a tyrosine added at the N-terminus. It is a fragment, not the hormone: it lacks the regions of growth hormone that bind the growth hormone receptor. No receptor target for the fragment itself has been established in the published literature, so none is stated here.

Also known as
AOD9604 · hGH 177-191

Structure and mechanism only. Nothing above describes what this compound is for, and no dose appears anywhere on this page.

Reading on this compound

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