SLU332

SLU-PP-332

Not a peptide. A small-molecule pyrimidinone described in the literature as a pan-agonist of the estrogen-related receptors, a family of orphan nuclear receptors — intracellular transcription factors, not the cell-surface receptors most compounds in this directory act on.

No registered human study names SLU-PP-332 as an intervention. ClinicalTrials.gov holds no trial of it, so there is no trial evidence to read — a fact about the public record rather than proof the compound does nothing. No FDA-approved product contains SLU-PP-332. 10 papers naming it were published in the last ten years.

Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Counts include only trials whose registered intervention names SLU-PP-332; the registry search is fuzzy, so every match is re-checked. None of this says whether SLU-PP-332 works or is safe.

FDA status

Research only

Human studies

0

Furthest phase

Papers, 10 yr

10

Readership

4,136

monthly average, Feb–Jul 2026

Tracking since 2026-07-29 · About this data

What has actually been tested in humans

X

No registered human study

0

Registered human studies

None

No FDA-approved product contains it

No study of SLU-PP-332 in humans is registered on ClinicalTrials.gov. That is a fact about the public record, not a statement that the compound does nothing — but it does mean there is no trial evidence to read, and anyone telling you otherwise should be asked for the registration number. The grade is mechanical: it is computed from the registry and the FDA record alone, and it grades how much is known, never whether a compound is good or safe. Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Check the query.

What SLU-PP-332 is, and what it has been studied for

SLU-PP-332 is tracked here.

No registered trial names SLU-PP-332 as an intervention, so there is no condition it has been formally studied in. It does have a literature: 10 indexed papers name it in the last ten years. That work is laboratory and animal research, and a paper is not a trial.

Is anyone studying SLU-PP-332?

Papers published each year that name SLU-PP-332 in the title or abstract, with the clinical trials that started in the same year marked beneath. Ten calendar years.

0134517181920212223242526
Vertical axis: papers published that year. Bar for 2026 is hatched because that year is still running.
Publications and trials naming SLU-PP-332, by year
YearPublicationsTrials startedComplete year
201700Yes
201800Yes
201900Yes
202000Yes
202100Yes
202200Yes
202330Yes
202420Yes
202520Yes
202650No

10 papers between 2017 and 2026. A paper counts when “SLU-PP-332” appears in its title or abstract — phrase-matched, so a paper mentioning the words separately is not counted. The total is a single query over the whole window, which is why it does not equal the bars added together: PubMed files a paper under both its electronic and its print publication date, so one paper can appear in two years. Publication volume measures scientific attention, not whether a compound works: a well-studied compound can be well-studied and ineffective. Sources: PubMed and ClinicalTrials.gov · collected 2026-08-02.

Published research on SLU-PP-332

10 indexed papers name SLU-PP-332 in their title or abstract. These are the 8 PubMed ranks most relevant. Listing a paper is not a judgement about it, and none of these is summarised here — follow the link and read what it says.

  1. A Synthetic ERR Agonist Alleviates Metabolic Syndrome

    Billon C, Schoepke E, Avdagic A, et al.The Journal of pharmacology and experimental therapeutics2024

    PMID 3773980610.1124/jpet.123.001733

  2. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function

    Xu W, Billon C, Li H, et al.Circulation2024

    PMID 3796190310.1161/CIRCULATIONAHA.123.066542

  3. In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential

    Möller T, Krug O, Thevis MRapid communications in mass spectrometry : RCM2026

    PMID 4158868710.1002/rcm.70039

  4. Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling

    Okda HE, Zhao P, Hayes M, et al.International journal of biological macromolecules2026

    PMID 4185044910.1016/j.ijbiomac.2026.151450

  5. An orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity

    Billon C, Appourchaux K, Côté I, et al.The Journal of pharmacology and experimental therapeutics2026

    PMID 4142104710.1016/j.jpet.2025.103787

  6. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

    Billon C, Sitaula S, Banerjee S, et al.ACS chemical biology2023

    PMID 3698891010.1021/acschembio.2c00720

  7. Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes

    Avliyakulov NK, Sobolevsky T, Ahrens EDrug testing and analysis2026

    PMID 4168841510.1002/dta.70035

  8. Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

    Wang XX, Myakala K, Libby AE, et al.The American journal of pathology2023

    PMID 3771794010.1016/j.ajpath.2023.07.008

Collected 2026-08-02from PubMed, phrase-matched on “SLU-PP-332” in title and abstract. Run the same search.

About SLU-PP-332

Not a peptide. A small-molecule pyrimidinone described in the literature as a pan-agonist of the estrogen-related receptors, a family of orphan nuclear receptors — intracellular transcription factors, not the cell-surface receptors most compounds in this directory act on.

Structure and mechanism only. Nothing above describes what this compound is for, and no dose appears anywhere on this page.

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