PP4
Palmitoyl pentapeptide-4
Palmitic acid conjugated to the pentapeptide Lys-Thr-Thr-Lys-Ser, a sequence found in type I procollagen. The fatty-acid chain is present to carry the peptide through the lipid layers of the stratum corneum, which a bare pentapeptide does not cross. It is regulated as a cosmetic ingredient.
No registered human study names Palmitoyl pentapeptide-4 as an intervention. ClinicalTrials.gov holds no trial of it, so there is no trial evidence to read — a fact about the public record rather than proof the compound does nothing. No FDA-approved product contains Palmitoyl pentapeptide-4. 5 papers naming it were published in the last ten years.
Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Counts include only trials whose registered intervention names Palmitoyl pentapeptide-4; the registry search is fuzzy, so every match is re-checked. None of this says whether Palmitoyl pentapeptide-4 works or is safe.
FDA status
Research only
Human studies
0
Furthest phase
—
Papers, 10 yr
5
Readership
603
monthly average, Feb–Jul 2026
Tracking since 2026-07-29 · About this data
What has actually been tested in humans
No registered human study
0
Registered human studies
None
No FDA-approved product contains it
No study of Palmitoyl pentapeptide-4 in humans is registered on ClinicalTrials.gov. That is a fact about the public record, not a statement that the compound does nothing — but it does mean there is no trial evidence to read, and anyone telling you otherwise should be asked for the registration number. The grade is mechanical: it is computed from the registry and the FDA record alone, and it grades how much is known, never whether a compound is good or safe. Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Check the query.
What Palmitoyl pentapeptide-4 is, and what it has been studied for
Palmitoyl pentapeptide-4 is tracked here. Its FDA substance identifier is KK181SM5JG.
No registered trial names Palmitoyl pentapeptide-4 as an intervention, so there is no condition it has been formally studied in. It does have a literature: 5 indexed papers name it in the last ten years. That work is laboratory and animal research, and a paper is not a trial.
Is anyone studying Palmitoyl pentapeptide-4?
Papers published each year that name Palmitoyl pentapeptide-4 in the title or abstract, with the clinical trials that started in the same year marked beneath. Ten calendar years.
| Year | Publications | Trials started | Complete year |
|---|---|---|---|
| 2017 | 0 | 0 | Yes |
| 2018 | 0 | 0 | Yes |
| 2019 | 0 | 0 | Yes |
| 2020 | 0 | 0 | Yes |
| 2021 | 0 | 0 | Yes |
| 2022 | 0 | 0 | Yes |
| 2023 | 1 | 0 | Yes |
| 2024 | 1 | 0 | Yes |
| 2025 | 3 | 0 | Yes |
| 2026 | 1 | 0 | No |
5 papers between 2017 and 2026. A paper counts when “Palmitoyl pentapeptide-4” appears in its title or abstract — phrase-matched, so a paper mentioning the words separately is not counted. The total is a single query over the whole window, which is why it does not equal the bars added together: PubMed files a paper under both its electronic and its print publication date, so one paper can appear in two years. Publication volume measures scientific attention, not whether a compound works: a well-studied compound can be well-studied and ineffective. Sources: PubMed and ClinicalTrials.gov · collected 2026-08-02.
Published research on Palmitoyl pentapeptide-4
5 indexed papers name Palmitoyl pentapeptide-4 in their title or abstract. These are the 5 PubMed ranks most relevant. Listing a paper is not a judgement about it, and none of these is summarised here — follow the link and read what it says.
- Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study
- Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin
- A framework for the safety evaluation of peptides in cosmetics
Collected 2026-08-02from PubMed, phrase-matched on “Palmitoyl pentapeptide-4” in title and abstract. Run the same search.
About Palmitoyl pentapeptide-4
Palmitic acid conjugated to the pentapeptide Lys-Thr-Thr-Lys-Ser, a sequence found in type I procollagen. The fatty-acid chain is present to carry the peptide through the lipid layers of the stratum corneum, which a bare pentapeptide does not cross. It is regulated as a cosmetic ingredient.
- Also known as
- Palmitoyl pentapeptide-3 · pal-KTTKS
Structure and mechanism only. Nothing above describes what this compound is for, and no dose appears anywhere on this page.
Reading on this compound
All articles →PepRack articles that reference this compound. This is not a news feed — we syndicate nothing and publish no datelines.
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