DSIP

DSIP

A nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit cerebral venous blood. Neither a gene encoding it nor a receptor for it has been established in the published literature, which is unusual for a peptide described more than fifty years ago.

No registered human study names DSIP as an intervention. ClinicalTrials.gov holds no trial of it, so there is no trial evidence to read — a fact about the public record rather than proof the compound does nothing. No FDA-approved product contains DSIP. 11 papers naming it were published in the last ten years.

Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Counts include only trials whose registered intervention names DSIP; the registry search is fuzzy, so every match is re-checked. None of this says whether DSIP works or is safe.

FDA status

Research only

Human studies

0

Furthest phase

Papers, 10 yr

11

Readership

2,664

monthly average, Feb–Jul 2026

Tracking since 2026-07-29 · About this data

What has actually been tested in humans

X

No registered human study

0

Registered human studies

None

No FDA-approved product contains it

No study of DSIP in humans is registered on ClinicalTrials.gov. That is a fact about the public record, not a statement that the compound does nothing — but it does mean there is no trial evidence to read, and anyone telling you otherwise should be asked for the registration number. The grade is mechanical: it is computed from the registry and the FDA record alone, and it grades how much is known, never whether a compound is good or safe. Collected 2026-08-02 from ClinicalTrials.gov and Drugs@FDA. Check the query.

What DSIP is, and what it has been studied for

DSIP is classified by ChEMBL as a protein.

No registered trial names DSIP as an intervention, so there is no condition it has been formally studied in. It does have a literature: 11 indexed papers name it in the last ten years. That work is laboratory and animal research, and a paper is not a trial.

Is anyone studying DSIP?

Papers published each year that name DSIP in the title or abstract, with the clinical trials that started in the same year marked beneath. Ten calendar years.

0123417181920212223242526
Vertical axis: papers published that year. Bar for 2026 is hatched because that year is still running.
Publications and trials naming DSIP, by year
YearPublicationsTrials startedComplete year
201720Yes
201810Yes
201900Yes
202010Yes
202130Yes
202200Yes
202310Yes
202420Yes
202510Yes
202600No

11 papers between 2017 and 2026. A paper counts when “DSIP” appears in its title or abstract — phrase-matched, so a paper mentioning the words separately is not counted. The total is a single query over the whole window, which is why it does not equal the bars added together: PubMed files a paper under both its electronic and its print publication date, so one paper can appear in two years. Publication volume measures scientific attention, not whether a compound works: a well-studied compound can be well-studied and ineffective. Sources: PubMed and ClinicalTrials.gov · collected 2026-08-02.

Published research on DSIP

11 indexed papers name DSIP in their title or abstract. These are the 8 PubMed ranks most relevant. Listing a paper is not a judgement about it, and none of these is summarised here — follow the link and read what it says.

  1. Delta sleep-inducing peptide (DSIP): a still unresolved riddle

    Kovalzon VM, Strekalova TVJournal of neurochemistry2006

    PMID 1653967910.1111/j.1471-4159.2006.03693.x

  2. Delta-sleep-inducing peptide (DSIP): an update

    Graf MV, Kastin AJPeptides1986

    PMID 355072610.1016/0196-9781(86)90148-8

  3. DSIP in insomnia

    Schneider-Helmert DEuropean neurology1984

    PMID 639192510.1159/000115714

  4. DSIP in sleep disturbances

    Schneider-Helmert DEuropean neurology1986

    PMID 375811910.1159/000116097

  5. The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats

    Tsunashima K, Masui A, Kato NBrain research1990

    PMID 232284310.1016/0006-8993(90)90748-z

  6. Die Anfänge moderner Schlafforschung

    Mächler HRZurcher medizingeschichtliche Abhandlungen1994

    PMID 11630267

  7. Delta-sleep-inducing peptide (DSIP): a review

    Graf MV, Kastin AJNeuroscience and biobehavioral reviews1984

    PMID 614513710.1016/0149-7634(84)90022-8

  8. Biochemical regulation of non-rapid-eye-movement sleep

    Obal F Jr, Krueger JMFrontiers in bioscience : a journal and virtual library2003

    PMID 1270003110.2741/1033

Collected 2026-08-02from PubMed, phrase-matched on “DSIP” in title and abstract. Run the same search.

About DSIP

A nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit cerebral venous blood. Neither a gene encoding it nor a receptor for it has been established in the published literature, which is unusual for a peptide described more than fifty years ago.

Also known as
Delta sleep-inducing peptide

Structure and mechanism only. Nothing above describes what this compound is for, and no dose appears anywhere on this page.

Reading on this compound

All articles

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